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oai:uvadoc.uva.es:10324/351622025-03-26T19:10:03Zcom_10324_35294com_10324_952com_10324_894com_10324_1173com_10324_931com_10324_31059com_10324_954col_10324_35295col_10324_1371col_10324_31061

Cantera Ruiz De Pellon, Sara Bordel Velasco, Sergio Lebrero Fernández, Raquel Gancedo Verdejo, Juan García Encina, Pedro Antonio Muñoz Torre, Raúl 2019-03-21T10:04:12Z 2019-03-21T10:04:12Z 2019 World Journal of Microbiology and Biotechnology, 2019, 35:16 0959-3993 http://uvadoc.uva.es/handle/10324/35162 10.1007/s11274-018-2587-4 Producción Científica Despite the environmental relevance of CH4 and forthcoming stricter regulations, the development of cost-efficient and environmentally friendly technologies for CH4 abatement is still limited. To date, one of the most promising solutions for the mitigation of this important GHG consists of the bioconversion of CH4 into bioproducts with a high profit margin. In this context, methanotrophs have been already proven as cell-factories of some of the most expensive products synthesized by microorganisms. In the case of ectoine (1000 $ kg−1), already described methanotrophic genera such as Methylomicrobium can accumulate up to 20% (ectoine wt−1) using methane as the only carbon source. Moreover, α-methanotrophs, such as Methylosynus and Methylocystis, are able to store bioplastic concentrations up to 50–60% of their total cell content. More than that, methanotrophs are one of the greatest potential producers of methanol and exopolysaccharides. Although this methanotrophic factory could be enhanced throughout metabolic engineering, the valorization of CH4 into valuable metabolites has been already consistently demonstrated under continuous and discontinuous mode, producing more than one compound in the same bioprocess, and using both, single strains and specific consortia. This review states the state-of-the-art of this innovative biotechnological platform by assessing its potential and current limitations. Ministerio de Economía, Industria y Competitividad- FEDER (Proyect (CTM2015-73228-JIN, H2020- MSCA-IF-2016: CH4BioVal-GA:750126 and Red NOVEDAR) Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. Project UIC71) H2020- MSCA-IF-2016: CH4BioVal-GA:750126 application/pdf eng Springer info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Metano Methane Transformación biológica Bio-transformation Bio-conversion of methane into high profit margin compounds: an innovative, environmentally friendly and cost-effective platform for methane abatement info:eu-repo/semantics/article https://link.springer.com/article/10.1007/s11274-018-2587-4 info:eu-repo/grantAgreement/EC/H2020/750126 NO