2026-04-28T19:48:29Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/353282025-03-26T19:10:05Zcom_10324_22821com_10324_954com_10324_894col_10324_22822

Santos García, María Mercedes Serrano Dúcar, Sofía González Valdivieso, Juan Vallejo Vicente, Reinaldo Girotti ., Alessandra Cuadrado Curto, María Purificación Arias Vallejo, Francisco Javier 2019-04-03T11:35:42Z 2019-04-03T11:35:42Z 2018 Current Medicinal Chemistry, 2018. 25 p. 0929-8673 http://uvadoc.uva.es/handle/10324/35328 10.2174/0929867325666180508094637 Producción Científica Protein-based polymers are some of the most promising candidates for a new generation of innovative biomaterials as recent advances in genetic-engineering and biotechnological techniques mean that protein-based biomaterials can be designed and constructed with a high degree of complexity and accuracy. Moreover, their sequences, which are derived from structural protein-based modules, can easily be modified to include bioactive motifs that improve their functions and material-host interactions, thereby satisfying fundamental biological requirements. The accuracy with which these advanced polypeptides can be produced, and their versatility, self-assembly behavior, stimuli-responsiveness and biocompatibility, means that they have attracted increasing attention for use in biomedical applications such as cell culture, tissue engineering, protein purification, surface engineering and controlled drug delivery. The biopolymers discussed in this review are elastin-derived protein-based polymers which are biologically inspired and biomimetic materials. This review will also focus on the design, synthesis and characterization of these genetically encoded polymers and their potential utility for controlled drug and gene delivery, as well as in tissue engineering and regenerative medicine. European Social Fund (ESF) and European Regional Development Fund (ERDF) EU (NMP-2014-646075, HEALTH-F4-2011-278557, PITN-GA-2012-317306 and MSCA-ITN-2014-642687) Ministerio de Economía, Industria y Competitividad (Projects MAT2015-68901-R, MAT2016-79435-R and MAT2016-78903-R) Junta de Castilla y León (programa de apoyo a proyectos de investigación - Ref. Projects VA244U13 and VA313U14) application/pdf eng Benthan Science info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Biomateriales Biomaterials Elastina Elastin Ingeniería genética Genetic engineering Aplicaciones biomédicas Biomedical Applications Genetically Engineered Elastin-based Biomaterials for Biomedical Applications info:eu-repo/semantics/article http://www.eurekaselect.com/161911/article SI