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oai:uvadoc.uva.es:10324/353292025-03-26T19:10:04Zcom_10324_22821com_10324_954com_10324_894col_10324_22822

García Couce, Jomarien Campos, Yaima Torres, Susana Peón, Eduardo Fuentes, Gastón Almirall, Amisel Delgado, José Ángel Rodríguez Cabello, José Carlos Cruz Ricondo, Luis J. 2019-04-03T12:06:36Z 2018 Polymer, 2018, vol. 158. p. 279-288 0032-3861 http://uvadoc.uva.es/handle/10324/35329 10.1016/j.polymer.2018.10.068 Producción Científica Hydrophilic composites of poly (acrylamide-co-2-hydroxyethyl methacrylate) reinforced with hydroxyapatite were synthesized, characterized and evaluated as drug delivery systems. The results show a strong dependence of the polymer composition, the degree of crosslinking and the homogeneity of the particles dispersion (filler or the mixed drug) in the characteristics that were analyzed. The mechanical properties were better while the swelling and the diffusion coefficient were worse than hydrogels with cefazolin of similar compositions. Additionally, a new information criterion was used to elucidate the best fit. The drug diffusion into the medium was anomalous with a tendency towards Case II transport, indicating that under certain conditions zero-order diffusion could be achieved. This fact suggests that these materials could be used in the manufacture of medical devices for the controlled delivery of drugs and active or biological principles, significantly improving therapeutic procedures today. 2020-12-06 2020-12-06 European Union (Erasmus PLUS project NL01-KA 107-008639; Erasmus MUNDUS LINDO ML14PD1157) application/pdf eng Elsevier info:eu-repo/semantics/openAccess © 2019 Elsevier Criterio de información Information criterion Administración de medicamentos Drug delivery Poliacrilamida Polyacrylamide A novel information criterion to elucidate a drug delivery mechanism from poly (acrylamide-co-2-hydroxyethyl methacrylate) reinforced with hydroxyapatite composite info:eu-repo/semantics/article https://www.sciencedirect.com/science/article/pii/S0032386118309959 SI