2026-04-27T21:55:07Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/377192025-03-26T19:10:02Zcom_10324_28542com_10324_952com_10324_894com_10324_1187com_10324_931col_10324_28543col_10324_1408

Rodríguez Ferrer, Patricia Sanz Novo, Miguel Maestro Fernández, Alicia Andrés García, José María Pedrosa Sáez, Rafael 2019 Producción Científica Enantioenriched 3‐amino‐3‐substituted oxindoles have been obtained by addition of different nucleophiles to N‐Boc ketimines derived from isatin catalyzed by chiral bifunctional supported thioureas. The Mannich reaction occurs with excellent enantioselection, but poor diastereoselection when prochiral nucleophiles were used. The supported catalyst were recovered and reused for five times without loss of activity. The mixture of diastereoisomers formed when a prochiral structure was used as nucleophile was converted into a single enantioenriched pyrazolyl derivative. application/pdf http://uvadoc.uva.es/handle/10324/37719 eng Wiley Online Library Synthesis of Enantioenriched 3-Amino-3-Substituted Oxindoles by Stereoselective Mannich Reaction Catalyzed by Supported Bifunctional Thioureas info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana