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00925njm 22002777a 4500 dc Rodríguez Ferrer, Patricia author Sanz Novo, Miguel author Maestro Fernández, Alicia author Andrés García, José María author Pedrosa Sáez, Rafael author 2019 Enantioenriched 3‐amino‐3‐substituted oxindoles have been obtained by addition of different nucleophiles to N‐Boc ketimines derived from isatin catalyzed by chiral bifunctional supported thioureas. The Mannich reaction occurs with excellent enantioselection, but poor diastereoselection when prochiral nucleophiles were used. The supported catalyst were recovered and reused for five times without loss of activity. The mixture of diastereoisomers formed when a prochiral structure was used as nucleophile was converted into a single enantioenriched pyrazolyl derivative. Advanced Synthesis and Catalysis, 2019, vol. 361, n. 15. p. 3645-3655 1615-4169 http://uvadoc.uva.es/handle/10324/37719 10.1002/adsc.201900414 Synthesis of Enantioenriched 3-Amino-3-Substituted Oxindoles by Stereoselective Mannich Reaction Catalyzed by Supported Bifunctional Thioureas