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oai:uvadoc.uva.es:10324/399152025-11-25T11:48:32Zcom_10324_1186com_10324_931com_10324_894com_10324_28542com_10324_952com_10324_28708com_10324_954col_10324_1404col_10324_28543col_10324_28709

Álvarez Miguel, Lucía Álvarez Miguel, Ines Martín Álvarez, José Miguel Álvarez González, Celedonio Manuel Rogez, Guillaume García Rodríguez, Raúl Miguel San José, Daniel 2019-12-17T12:00:46Z 2019-12-17T12:00:46Z 2019 Dalton Transactions, 2019, n. 48, p. 17544-17555 1477-9234 http://uvadoc.uva.es/handle/10324/39915 10.1039/c9dt03822a In the study presented herein, we explore the ability of copper complexes with coordinated pyridine-2-carboxaldehyde (pyca) or 2-acetylpyridine (acepy) ligands to promote the addition of amines (Schiff condensation) and other nucleophiles such as alcohols (hemiacetal formation). Distinct reactivity patterns are observed: unlike pyca complexes, acepy copper complexes can promote self-aldol addition. The introduction of a flexible chain via Schiff condensation with β-alanine allows the possibility of chelate ring ring-opening processes mediated by pH. Further derivatization of the complex [CuCl(py-2-C(H)[double bond, length as m-dash]NCH2CH2COO)] is possible by replacing its chloride ligand with different pseudohalogens (N3−, NCO− and NCS−). In addition to the change in their magnetism, which correlates with their solid-state structures, more unexpected effects in their cytotoxicity and relaxitivities are observed, which determines their possibility to be used as MRI contrast agents. The replacement of a chloride by another pseudohalogen, although a simple strategy, can be used to critically change the cytotoxicity of the Schiff base copper (II) complex and its selectivity towards specific cell lines. eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ © 2019 Royal Society of Chemistry Attribution-NonCommercial-NoDerivatives 4.0 Internacional Copper complexes for the promotion of iminopyridine ligands derived from β-alanine and self-aldol additions: relaxivity and cytotoxic properties info:eu-repo/semantics/article