2026-04-27T20:11:02Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/409922025-02-13T10:41:02Zcom_10324_1181com_10324_931com_10324_894col_10324_1387

00925njm 22002777a 4500 dc Tejero Del Rio, Jesús author Jiménez López, María del Pilar author Quinto Fernández, Emiliano José author Córdoba Diaz, Damián author Garrosa García, Manuel author Córdoba Diaz, Manuel author Gayoso Rodríguez, Manuel José author Girbés Juan, Tomás author 2015 Sambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been somewhat restricted due to the presence of bioactive proteins or/and low molecular weight compounds whose ingestion could trigger deleterious effects. Over the last few years, the chemical and pharmacological characteristics of Sambucus species have been investigated. Among the proteins present in Sambucus species both type 1, and type 2 ribosome-inactivating proteins (RIPs), and hololectins have been reported. The biological role played by these proteins remains unknown, although they are conjectured to be involved in defending plants against insect predators and viruses. These proteins might have an important impact on the nutritional characteristics and food safety of elderberries. Type 2 RIPs are able to interact with gut cells of insects and mammals triggering a number of specific and mostly unknown cell signals in the gut mucosa that could significantly affect animal physiology. In this paper, we describe all known RIPs that have been isolated to date from Sambucus species, and comment on their antiviral and entomotoxic effects, as well as their potential uses. Molecules, 2015, vol. 20, n. 2. p. 2364-2387 1420-3049 http://uvadoc.uva.es/handle/10324/40992 10.3390/molecules20022364 Elderberries: A source of ribosome-inactivating proteins with lectin activity