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oai:uvadoc.uva.es:10324/41812025-02-21T10:34:48Zcom_10324_1181com_10324_931com_10324_894col_10324_1387

Garrote Adrados, José Antonio Gómez, Emma León, Alberto José Bernardo Ordiz, David Calvo Romero, María Del Carmen Fernández Salazar, Luis Ignacio Blanco Quiros, Alfredo Arranz Sanz, Eduardo 2014-01-16T12:37:55Z 2014-01-16T12:37:55Z 2008 Drug Target Insights, 3. p. 1-11 1177-3928 http://uvadoc.uva.es/handle/10324/4181 1 3 11 Drug target insights Producción Científica The aims of the study were to assess the usefulness of expression macroarrays to determine the pattern of expression of cytokines, chemokines and molecules related to immune system activation pathways, in non-stimulated intact intestinal tissue specimens from patients with active CD (aCD) and on a gluten-free diet (GFD), to compare it with two groups of controls with either normal or altered mucosal architecture, and to establish putative targets for diagnostic markers or therapeutic intervention. We have experienced the lack of sensitivity to detect signal of genes with low level of expression. In spite of that, active CD seems to show a Th1 cytokine pattern, but with signs of Th2 activity. Cytokines such as IL-9, IL-11, IL-21 or MIF might be involved in mucosal infl ammation in CD. In GFD, some memory cells and DC’s activity remains, and factors that maintain this remnant activation might be responsible of the fast mucosal response on gluten challenge. STAT3 and STAT5 pathways, and their regulatory molecules SOCS’s may result keys for understanding mucosal infl ammation in gut and putative targets for further research. application/pdf eng Instituto de Biología y Genética Molecular (IBGM) info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Libertas Academica Attribution-NonCommercial-NoDerivatives 4.0 International Enfermedad celíaca Citokine, chemokine and immune activation pathway profiles in celiac disease : an immune system activity screening by expression macroarrays. info:eu-repo/semantics/article SI