2026-05-05T20:53:07Zhttps://uvadoc.uva.es/oai/request
oai:uvadoc.uva.es:10324/423882021-06-24T07:27:55Zcom_10324_22821com_10324_954com_10324_894col_10324_22822
UVaDOC author Acosta Rodríguez, Sergio author Ye, Zhou author Aparicio, Conrado author Alonso Rodrigo, Matilde author Rodríguez Cabello, José Carlos 2020-09-21T12:23:29Z 2020-09-21T12:23:29Z 2020 Biomacromolecules 2020 (in press) 1525-7797 http://uvadoc.uva.es/handle/10324/42388 10.1021/acs.biomac.0c00865 Biomacromolecules 1526-4602 Antimicrobial peptides (AMPs) have attracted great interest as they constitute one of the most promising alternatives against drug-resistant infections. Their amphipathic nature provides them antimicrobial and immunomodulatory properties but also the ability to selfassemble into supramolecular nanostructures. Here, we propose their use as selfassembling domains to drive hierarchical organization of intrinsically disordered protein polymers (IDPPs). Using a modular approach, hybrid protein-engineered polymers were recombinantly produced, thus combining designer AMPs and a thermoresponsive IDPP, an elastin-like recombinamer (ELR). We exploited the ability of these AMPs and ELRs to self-assemble to develop supramolecular nanomaterials by way of a dual-assembly process. First, the AMPs trigger the formation of nanofibers, then the thermoresponsiveness of the ELRs enables assembly into fibrillar aggregates. The interplay between the assembly of AMPs and ELRs provides an innovative molecular tool in the development of self-assembling nanosystems with potential use for biotechnological and biomedical applications. spa Dual Self-Assembled Nanostructures from Intrinsically Disordered Protein Polymers with LCST Behavior and Antimicrobial Peptides info:eu-repo/semantics/article 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URL https://uvadoc.uva.es/bitstream/10324/42388/1/Dual%20self-assembled.pdf File MD5 8b50d8b56051f1b15e81082ea28ca4ad 1301827 application/pdf Dual self-assembled.pdf