2026-04-14T15:18:45Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/433282021-06-24T07:27:56Zcom_10324_22821com_10324_954com_10324_894col_10324_22822

González Pérez, Miguel González de Torre, Israel Alonso Rodrigo, Matilde Rodríguez Cabello, José Carlos 2020-11-05T11:28:25Z 2020-11-05T11:28:25Z 2020 Biomacromolecules 2020, 21, 4149−4158 1525-7797 http://uvadoc.uva.es/handle/10324/43328 10.1021/acs.biomac.0c00939 4149 10 4158 Biomacromolecules 21 1526-4602 Diffusion of organic and inorganic molecules controls most industrial and biological processes that occur in a liquid phase. Although significant efforts have been devoted to the design and operation of large-scale purification systems, diffusion devices with adjustable biochemical characteristics have remained difficult to achieve. In this regard, micrometer-scale, bioinspired membranes with tunable diffusion properties have been engineered by covalent cross-linking of two elastin-like recombinamers (ELRs) at a liquid−liquid interface. The covalent approach selected provides the desired ELR-based membranes with structural support, and modulation of the concentration of the polypeptides employed confers direct control of the thickness, pore size, and diffusive properties over a broad range of molecular weights (4−150 kDa). The recombinant and versatile nature of the proteinaceous building blocks employed further paves the way to engineering bioactive motifs within the membrane scaffold, thereby widening their applicability in the biological field. spa info:eu-repo/semantics/openAccess Controlled Production of Elastin-like Recombinamer Polymer-Based Membranes at a Liquid–Liquid Interface by Click Chemistry info:eu-repo/semantics/article