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oai:uvadoc.uva.es:10324/446242021-06-24T07:17:51Zcom_10324_43677com_10324_954com_10324_894col_10324_43678

The FASTK family of proteins : emerging regulators of mitochondrial RNA biology Jourdain, Alexis A. Popow, Johannes Fuente García, Miguel Ángel de la Martinou, Jean-Claude Anderson, Paul Simarro Grande, María Mitochondrial RNA ARN mitocondrial Proteins Proteínas Producción Científica The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its homologs FASTKD1–5 are architecturally related RNA-binding proteins, each having a different function in the regulation of mitochondrial RNA biology, from mRNA processing and maturation to ribosome assembly and translation. In this review, we outline the structure, evolution and function of these FASTK proteins and discuss the individual role that each has in mitochondrial RNA biology. In addition, we highlight the aspects of FASTK research that still require more attention. Swiss National Science Foundation (grant 310030B_160257/1) Junta de Castilla y León (grants BIO/VA20/15 and BIO/VA21/15) 2021-01-07T08:43:51Z 2021-01-07T08:43:51Z 2017 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Nucleic Acids Research, 2017, vol. 45, n. 19. p. 10941-10947 1362-4962 http://uvadoc.uva.es/handle/10324/44624 10.1093/nar/gkx772 eng https://academic.oup.com/nar/article/45/19/10941/4161989 Attribution-NonCommercial-NoDerivatives 4.0 Internacional info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ © 2017 Oxford University Press application/pdf Oxford University Press https://uvadoc.uva.es/bitstream/10324/44624/4/FASTK-family-of-proteins.pdf.jpg Hispana TEXT http://creativecommons.org/licenses/by-nc-nd/4.0/ UVaDOC. Repositorio Documental de la Universidad de Valladolid http://uvadoc.uva.es/handle/10324/44624