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oai:uvadoc.uva.es:10324/446242021-06-24T07:17:51Zcom_10324_43677com_10324_954com_10324_894col_10324_43678

00925njm 22002777a 4500 dc Jourdain, Alexis A. author Popow, Johannes author Fuente García, Miguel Ángel de la author Martinou, Jean-Claude author Anderson, Paul author Simarro Grande, María author 2017 The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its homologs FASTKD1–5 are architecturally related RNA-binding proteins, each having a different function in the regulation of mitochondrial RNA biology, from mRNA processing and maturation to ribosome assembly and translation. In this review, we outline the structure, evolution and function of these FASTK proteins and discuss the individual role that each has in mitochondrial RNA biology. In addition, we highlight the aspects of FASTK research that still require more attention. Nucleic Acids Research, 2017, vol. 45, n. 19. p. 10941-10947 1362-4962 http://uvadoc.uva.es/handle/10324/44624 10.1093/nar/gkx772 The FASTK family of proteins : emerging regulators of mitochondrial RNA biology