2026-04-14T13:19:59Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/454612025-02-13T09:31:47Zcom_10324_1138com_10324_931com_10324_894col_10324_1226

Martín Fernández, Marta Vaquero Roncero, Luis Mario Almansa Mora, Raquel Gómez Sánchez, Esther Martín, Silvia Tamayo Gómez, Eduardo Esteban Velasco, María Carmen Ruiz Granado, Patricia Aragón, Marta Calvo, Dolores Rico Feijoo, Jesús Ortega, A. Gómez Pesquera, Estefanía Lorenzo López, Mario López Sánchez, Jaime Doncel, Cristina González Sánchez, Carmen Álvarez, D. Zarca, E. Ríos Llorente, Alberto Díaz Álvarez, A. Sánchez Barrado, Elisa Andaluz Ojeda, David Calvo Vecino, José María Muñoz Bellvís, Luis Gómez Herreras, José Ignacio Abad Molina, Cristina Bermejo Martín, Jesús Francisco Aldecoa Álvarez Santullano, César Enrique Heredia Rodríguez, María 2020 Producción Científica Background: Stratification of the severity of infection is currently based on the Sequential Organ Failure Assessment (SOFA) score, which is difficult to calculate outside the ICU. Biomarkers could help to stratify the severity of infection in surgical patients. Methods: Levels of ten biomarkers indicating endothelial dysfunction, 22 indicating emergency granulopoiesis, and six denoting neutrophil degranulation were compared in three groups of patients in the first 12 h after diagnosis at three Spanish hospitals. Results: There were 100 patients with infection, 95 with sepsis and 57 with septic shock. Seven biomarkers indicating endothelial dysfunction (mid-regional proadrenomedullin (MR-ProADM), syndecan 1, thrombomodulin, angiopoietin 2, endothelial cell-specific molecule 1, vascular cell adhesion molecule 1 and E-selectin) had stronger associations with sepsis than infection alone. MR-ProADM had the highest odds ratio (OR) in multivariable analysis (OR 11·53, 95 per cent c.i. 4·15 to 32·08; P = 0·006) and the best area under the curve (AUC) for detecting sepsis (0·86, 95 per cent c.i. 0·80 to 0·91; P < 0·001). In a comparison of sepsis with septic shock, two biomarkers of neutrophil degranulation, proteinase 3 (OR 8·09, 1·34 to 48·91; P = 0·028) and lipocalin 2 (OR 6·62, 2·47 to 17·77; P = 0·002), had the strongest association with septic shock, but lipocalin 2 exhibited the highest AUC (0·81, 0·73 to 0·90; P < 0·001). Conclusion: MR-ProADM and lipocalin 2 could be alternatives to the SOFA score in the detection of sepsis and septic shock respectively in surgical patients with infection. application/pdf http://uvadoc.uva.es/handle/10324/45461 eng Oxford University Press Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana