2026-04-28T21:22:59Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/455102024-12-18T08:38:12Zcom_10324_1138com_10324_931com_10324_894col_10324_1226

Heredia Rodríguez, María Bustamante Munguira, Juan Lorenzo López, Mario Gómez Sánchez, Esther Álvarez González, Francisco Javier Fierro Lorenzo, María Inmaculada Conejo Jorge, Esther Tamayo Gómez, Eduardo 2021-03-08T09:11:23Z 2021-03-08T09:11:23Z 2017 Journal of Surgical Research, 2017, vol. 212. p.187-194 0022-4804 http://uvadoc.uva.es/handle/10324/45510 10.1016/j.jss.2017.01.021 Producción Científica Background: Sepsis is strongly associated with an increased risk of postoperative mortality, longer length of hospital stay, and elevated health care costs. Early clinical symptoms overlap with those of systemic inflammatory response syndrome, a response that commonly occurs after cardiac surgery with cardiopulmonary bypass. Since a combination of biomarkers has been demonstrated to improve the prediction of postoperative infection, the objective of the present study was to test whether the combination of C-reactive protein (CRP), white blood cells (WBC), and procalcitonin (PCT) is able to predict postoperative infection in a large cohort of cardiac surgery patients. Material and methods: Case-control study involving 423 patients who underwent cardiac surgery with cardiopulmonary bypass. Patients were retrospectively classified into two groups based on whether they developed severe sepsis or septic shock during the postoperative period. Blood samples for biological measurements (PCT, CRP, and WBC) were drawn on the first day in the intensive care unit, then once daily in the morning until the 10th postoperative day. Results: CRP median values were similar in both groups. WBC and PCT median values were significantly higher in patients with infection than without during the first 10 postoperative days. With elevation cutoffs ≤3 times (OR: 4.058; 95% CI: 2.206-7.463; P = 0.001) and ≥4 times (OR: 10.274, 95% CI: 3.690-28.604; P < 0.001), the median value for PCT (1.7 ng/mL) and/or WBC (13,000 cells/mm3) on the second postoperative day was significantly associated with the development of infection. Conclusions: The goal of this study was to use a large cohort of cardiac surgery patients to ensure that the results were representative of this population. The combination of PCT and WBC levels over the first three postoperative days was able to predict postoperative infection within the 30 d following cardiac surgery. Instituto de Salud Carlos III (grant PI15/01451) Junta de Castilla y León (grant GRS1270/A/16) application/pdf eng Elsevier info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ © 2017 Elsevier Attribution-NonCommercial-NoDerivatives 4.0 Internacional Procalcitonin Procalcitonina leukocytes Leucocitos Biomarkers Biomarcadores Infection Infección Procalcitonin and white blood cells, combined predictors of infection in cardiac surgery patients info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0022480417300409?via%3Dihub SI