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Circulating neutrophil counts and mortality in septic shock Bermejo Martín, Jesús Francisco Tamayo Gómez, Eduardo Ruiz López del Prado, Gema Andaluz Ojeda, David Herrán Monge, Rubén Muriel Bombín, Arturo Muñoz Moreno, María Fe Heredia Rodríguez, María Citores, Rafael Gómez Herreras, José Ignacio Blanco Varela, Jesús Septic shock Choque séptico Validation cohort Cohorte de validación Endothelial damage Daño endotelial Producción Científica Polynuclear neutrophils can play dual roles in sepsis: on the one hand they mediate major antimicrobial activities and on the other hand they can contribute to the development of multiple organ failure [1]. Nonetheless, in spite of the importance of these cells in sepsis, the influence of the circulating neutrophil count (CNC) on the prognosis of septic patients with this pathology has not been properly evaluated. We analyzed the association between CNC and outcome in two cohorts of patients with diagnostic criteria of septic shock (SS) [2]: the first was recruited in the context of a single center study (EXPRESS study, discovery cohort, n = 195; Table 1), and the second in the context of a multi-centric study (GRECIA study, validation cohort, n = 194; Table 2). Written informed consent was obtained from each patient or their legal representative. The two studies were approved by the Research Ethics Committee of the Hospital Clínico Universitario, Valladolid, Spain (for the EXPRESS study) and Hospital Universitario Río Hortega, Valladolid, Spain (coordinating center for the GRECIA study). Instituto de Salud Carlos III (grant PI 10/01362) Junta de Castilla y León (grant BOCYL-D-26072010) 2021-03-09T11:59:17Z 2021-03-09T11:59:17Z 2014 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Critical Care, 2014, vol. 18. 4 p. 1364-8535 http://uvadoc.uva.es/handle/10324/45588 10.1186/cc13728 eng https://ccforum.biomedcentral.com/articles/10.1186/cc13728 Attribution-NonCommercial-NoDerivs 3.0 Unported info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/3.0/ © 2014 Springer Nature application/pdf Springer Nature https://uvadoc.uva.es/bitstream/10324/45588/4/Circulating-neutrophil-counts.pdf.jpg Hispana TEXT http://creativecommons.org/licenses/by-nc-nd/3.0/ UVaDOC. Repositorio Documental de la Universidad de Valladolid http://uvadoc.uva.es/handle/10324/45588