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oai:uvadoc.uva.es:10324/457002021-06-24T07:26:24Zcom_10324_41462com_10324_954com_10324_894col_10324_41463

Prevalence of HTLV infection in pregnant women in Spain Machuca, Ana Tuset, Concepción Soriano, Vincent Caballero, Estrella Aguilera, Antonio Ortiz de Lejarazu Leonardo, Raúl HTLV Leucemia Mujeres embarazadas 32 Ciencias Médicas Producción Científica Objective: To estimate the prevalence of HTLV infection among pregnant women in Spain. Methods: A commercial ELISA incorporating HTLV-I and HTLV-II antigens was used for HTLV antibody screening. Repeatedly reactive samples were further examined by western blot. Moreover, confirmation with PCR was performed when cells were available. Results: 20 366 pregnant women in 12 different Spanish cities were tested in a 3 year period (July 1996 to August 1999). 32 samples were repeatedly reactive by ELISA, and 10 of them were confirmed as positive by western blot (eight for HTLV-II and two for HTLV-I). In addition, three of 13 women who had an indeterminate western blot pattern yielded positive results for HTLV-II by PCR. All 11 HTLV-II infected women had been born in Spain, and all but one were former drug users. Seven of them were coinfected with HIV-1. One HTLV-I infected woman was from Peru, where HTLV is endemic and where she most probably was infected during sexual intercourse. Conclusion: The overall prevalence of HTLV infection among pregnant women in Spain is 0.064% (13/20 366), and HTLV-II instead of HTLV-I is the most commonly found variant. A strong relation was found among HTLV-II infection and specific epidemiological features, such as Spanish nationality and injecting drug use. Although HTLV-II can be vertically transmitted, mainly through breast feeding, both the low prevalence of infection and its lack of pathogenicity would not support the introduction of HTLV antenatal screening in Spain 2021-03-12T13:10:19Z 2021-03-12T13:10:19Z 2000 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sexually Transmitted Infections,2000, vol. 76 n. 5, p. 366-370 1368-4973 http://uvadoc.uva.es/handle/10324/45700 10.1136/sti.76.5.366 366 5 370 Sexually Transmitted Infections 76 eng https://sti.bmj.com/content/76/5/366 Attribution-NonCommercial-NoDerivatives 4.0 Internacional info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ BMJ Publishing Group application/pdf BMJ Publishing Group https://uvadoc.uva.es/bitstream/10324/45700/4/Prevalence-of-HTLV.pdf.jpg Hispana TEXT http://creativecommons.org/licenses/by-nc-nd/4.0/ UVaDOC. Repositorio Documental de la Universidad de Valladolid http://uvadoc.uva.es/handle/10324/45700