2026-05-05T19:28:00Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/474992023-04-20T11:20:47Zcom_10324_32522com_10324_952com_10324_894col_10324_32523

00925njm 22002777a 4500 dc López Urrutia, Luis author Alonso, Andrés author Nieto, Maria Luisa author Bayón Prieto, Yolanda author Orduña Domingo, Antonio author Sánchez Crespo, Mariano author 2000 Smooth lipopolysaccharide (S-LPS) and lipid A of Brucella abortus and Brucella melitensis induced the production of nitric oxide (NO) by rat adherent peritoneal cells, but they induced lower levels of production of NO than Escherichia coli LPS. The participation of the inducible isoform of NO synthase (iNOS) was confirmed by the finding of an increased expression of both iNOS mRNA and iNOS protein. These observations might help to explain (i) the acute outcome of Brucella infection in rodents, (ii) the low frequency of septic shock in human brucellosis, and (iii) the prolonged intracellular survival of Brucella in humans. Infection and Immunity, 2000, vol 68, n. 3, p. 1740-1745 0019-9567 https://uvadoc.uva.es/handle/10324/47499 10.1128/IAI.68.3.1740-1745.2000 1740 3 1745 Infection and Immunity 68 1098-5522 Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages