2026-04-30T05:02:34Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/485022021-09-05T18:32:20Zcom_10324_30605com_10324_894col_10324_41
UVaDOC
advisor
Aja Fernández, Santiago
advisor
Luis García, Rodrigo de
author
Planchuelo Gómez, Álvaro
editor
Universidad de Valladolid. Escuela Técnica Superior de Ingenieros de Telecomunicación
2021-09-03T07:43:00Z
2021-09-03T07:43:00Z
2021
https://uvadoc.uva.es/handle/10324/48502
10.35376/10324/48502
Migraine is one of the most common causes of disability, especially among young women. Despite
the high migraine prevalence and its consequences, currently there are no migraine biomarkers
and the diagnosis is exclusively based on the description of the symptoms by the patient. Furthermore,
the migraine pathophysiology is not completely understood yet. In order to find a
migraine biomarker and better understand the migraine pathophysiology, Magnetic Resonance
Imaging (MRI) has been employed thanks to its excellent tissue contrast and spatial resolution
using non-ionizing radiation. Multiple studies that have assessed gray matter and white matter
structure in patients with migraine have shown conflicting results, although some patterns such
as loss of gray matter volume have been widely described. From the clinical point of view, other
important assessments like the comparison between the two current main migraine types, Chronic
Migraine (CM) and Episodic Migraine (EM), have been barely carried out. Considering the technical
perspective, specific evaluations of the structural connections between gray matter regions
and the relationships between the MRI findings from different modalities have not been performed.
In the present doctoral thesis, the main objective was the characterization of gray matter and
white matter structural properties of patients with CM and EM. With regard to both migraine
groups, the comparison between the two migraine types through the employment of diverse MRI
processing techniques is also included in the main objective. The use of advanced and novel
diffusion measures not employed previously in the migraine literature was also considered to provide
an additional strategy for the assessment of white matter. An evaluation of the diffusion MRI
(dMRI) acquisition parameters in association with the sample size was carried out to identify
possible sources of the variability. Moreover, the structural connections between gray matter
regions through the white matter tracts were assessed, bearing in mind their possible relationship
with gray matter morphometry.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Migraña
Materia gris
Migraine
Gray Matter Morphometry
Diffusion Magnetic Resonance Imaging
A multimodal analysis of Magnetic Resonance Imaging for the study of brain abnormalities in migraine: gray matter morphometry, white matter integrity and structural connectivity
info:eu-repo/semantics/doctoralThesis
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https://uvadoc.uva.es/bitstream/10324/48502/1/TESIS-1865-210727.pdf
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TESIS-1865-210727.pdf