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00925njm 22002777a 4500 dc Alonso Revuelta, María Isabel author Martín, C. author Carnicero Gila, Estela María author Bueno i Torrens, David author Gato Casado, Ángel Luis author 2011 Embryonic-cerebrospinal fluid (E-CSF) plays crucial roles in early brain development including the control of neurogenesis. Although FGF2 and lipoproteins present in the E-CSF have previously been shown to be involved in neurogenesis, the main factor triggering this process remains unknown. E-CSF contains all-trans-retinol and retinol-binding protein involved in the synthesis of retinoic acid (RA), a neurogenesis inducer. In early chick embryo brain, only the mesencephalic-rombencephalic isthmus (IsO) is able to synthesize RA. Here we show that in chick embryo brain development: (1) E-CSF helps to control RA synthesis in the IsO by means of the RBP and all-trans-retinol it contains; (2) E-CSF has retinoic acid activity, which suggests it may act as a diffusion pathway for RA; and (3) the influence of E-CSF on embryonic brain neurogenesis is to a large extent due to its involvement in RA synthesis. These data help to understand neurogenesis from neural progenitor cells Developmental Dynamics, 2011 1058-8388 http://uvadoc.uva.es/handle/10324/4884 10.1002/dvdy.22657 1 0 10 Developmental dynamics 0 Neurología del desarrollo Cerebroespinal fluid control of neurogenesis induced by retinoic acid during early brain development