2026-04-14T16:03:37Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/48842021-07-06T08:33:19Zcom_10324_1132com_10324_931com_10324_894col_10324_1205

Cerebroespinal fluid control of neurogenesis induced by retinoic acid during early brain development Alonso Revuelta, María Isabel Martín, C. Carnicero Gila, Estela María Bueno i Torrens, David Gato Casado, Ángel Luis Neurología del desarrollo Producción Científica Embryonic-cerebrospinal fluid (E-CSF) plays crucial roles in early brain development including the control of neurogenesis. Although FGF2 and lipoproteins present in the E-CSF have previously been shown to be involved in neurogenesis, the main factor triggering this process remains unknown. E-CSF contains all-trans-retinol and retinol-binding protein involved in the synthesis of retinoic acid (RA), a neurogenesis inducer. In early chick embryo brain, only the mesencephalic-rombencephalic isthmus (IsO) is able to synthesize RA. Here we show that in chick embryo brain development: (1) E-CSF helps to control RA synthesis in the IsO by means of the RBP and all-trans-retinol it contains; (2) E-CSF has retinoic acid activity, which suggests it may act as a diffusion pathway for RA; and (3) the influence of E-CSF on embryonic brain neurogenesis is to a large extent due to its involvement in RA synthesis. These data help to understand neurogenesis from neural progenitor cells 2014-05-23T10:01:40Z 2015-05-23T23:40:09Z 2011 info:eu-repo/semantics/article Developmental Dynamics, 2011 1058-8388 http://uvadoc.uva.es/handle/10324/4884 10.1002/dvdy.22657 1 0 10 Developmental dynamics 0 eng info:eu-repo/semantics/openAccess Wiley SI