2026-05-05T18:31:37Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/497822021-11-08T21:46:45Zcom_10324_1187com_10324_931com_10324_894col_10324_1408
UVaDOC
author
Díez Poza, Carlos
author
Barbero Pérez, María Asunción
2021-11-08T12:42:38Z
2021-11-08T12:42:38Z
2021
Organic Letters, 2021, vol. 23, n. 21. p. 8385-8389
1523-7060
https://uvadoc.uva.es/handle/10324/49782
10.1021/acs.orglett.1c03121
The silyl-Prins cyclization of geminal vinylsilyl alcohols and aldehydes, promoted by TMSOTf, provides access to polysubstituted tetrahydropyrans in which the silyl group remains in the molecule and an aryl group has migrated from silicon to carbon. This domino silyl-Prins/aryl migration process is general and high-yielding for aryl, vinyl, or alkyl aldehydes. Moreover, cyclization proceeds with very high stereocontrol in a one-pot reaction in which both quaternary and tertiary stereogenic centers have been created.
eng
Atribución 4.0 Internacional
Unexpected domino Silyl-Prins/Aryl migration process from geminal Vinylsilyl alcohols
info:eu-repo/semantics/article
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https://uvadoc.uva.es/bitstream/10324/49782/1/Unexpected-domino.pdf
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1431050
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Unexpected-domino.pdf