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Díez Poza, Carlos Barbero Pérez, María Asunción 2021-11-08T12:42:38Z 2021-11-08T12:42:38Z 2021 Organic Letters, 2021, vol. 23, n. 21. p. 8385-8389 1523-7060 https://uvadoc.uva.es/handle/10324/49782 10.1021/acs.orglett.1c03121 The silyl-Prins cyclization of geminal vinylsilyl alcohols and aldehydes, promoted by TMSOTf, provides access to polysubstituted tetrahydropyrans in which the silyl group remains in the molecule and an aryl group has migrated from silicon to carbon. This domino silyl-Prins/aryl migration process is general and high-yielding for aryl, vinyl, or alkyl aldehydes. Moreover, cyclization proceeds with very high stereocontrol in a one-pot reaction in which both quaternary and tertiary stereogenic centers have been created. eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2021 The Authors Atribución 4.0 Internacional Unexpected domino Silyl-Prins/Aryl migration process from geminal Vinylsilyl alcohols info:eu-repo/semantics/article