2026-04-27T08:18:22Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/507592026-03-10T08:03:55Zcom_10324_1179com_10324_931com_10324_894col_10324_1306
Coca Rojo, Armando
Arias Cabrales, Carlos Enrique
Valencia Peláez, Ana Lucia
Burballa Tarrega, Carla Cristina
Bustamante Munguira, Juan
Redondo Pachón, María Dolores
Acosta Ochoa, María Isabel
Crespo Barrio, Marta
Bustamante Bustamante, Jesús
Mendiluce Herrero, Alicia
Pascual Santos, Julio
Pérez Saéz, María José
2021-12-02T08:21:38Z
2021-12-02T08:21:38Z
2020
Scientific Reports, 2020, vol. 10, 17109
2045-2322
https://uvadoc.uva.es/handle/10324/50759
10.1038/s41598-020-74295-3
1
1
10
Scientific Reports
10
2045-2322
Pre-transplant prognostic scores help to optimize donor/recipient allocation and to minimize organ
discard rates. Since most of these scores come from the US, direct application in non-US populations is
not advisable. The Survival Benefit Estimator (SBE), built upon the Estimated Post-Transplant Survival
(EPTS) and the Kidney Donor Profile Index (KDPI), has not been externally validated. We aimed to
examine SBE in a cohort of Spanish kidney transplant recipients. We designed a retrospective cohortbased study of deceased-donor kidney transplants carried out in two different Spanish hospitals.
Unadjusted and adjusted Cox models were applied for patient survival. Predictive models were
compared using Harrell’s C statistics. SBE, EPTS and KDPI were independently associated with patient
survival (p ≤ 0.01 in all models). Model discrimination measured with Harrell’s C statistics ranged from
0.57 (KDPI) to 0.69 (SBE) and 0.71 (EPTS). After adjustment, SBE presented similar calibration and
discrimination power to that of EPTS. SBE tended to underestimate actual survival, mainly among
high EPTS recipients/high KDPI donors. SBE performed acceptably well at discriminating posttransplant
survival in a cohort of Spanish deceased-donor kidney transplant recipients, although its use as the main allocation guide, especially for high KDPI donors or high EPTS recipients requires further testing.
eng
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2020 Springer
Atribución 4.0 Internacional
Riñones - Enfermedades - Tratamiento
Riñones - Trasplante
Survival
Supervivencia
Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients
info:eu-repo/semantics/article