2026-05-05T11:13:50Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/509392024-12-18T08:44:18Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

Morales Cerdán, Jose Maria Marcén Letosa, Roberto Castillo Caba, Domingo del Andrés Belmonte, Amado Gonzalez Molina, Miguel Oppenheimer Salinas, Federico Serón Micas, Daniel Gil Vernet, Salvador Lampreave Gaztelu, Ildefonso Gainza Ríos, Francisco Javier Valdés Cañedo, Francisco Antonio Cabello Díaz, Mercedes Anaya Fernández-Lomana, Fernando Escuín Sancho, Fernando Arias Rodríguez, Manuel Pallardó Mateu, Luis Bustamante Bustamante, Jesús 2012 Producción Científica Background. To describe the causes of graft loss, patient death and survival figures in kidney transplant patients in Spain based on the recipient’s age. Methods. The results at 5 years of post-transplant cardiovascular disease (CVD) patients, taken from a database on CVD, were prospectively analysed, i.e. a total of 2600 transplanted patients during 2000–2002 in 14 Spanish renal transplant units, most of them receiving their organ from cadaver donors. Patients were grouped according to the recipient’s age: Group A: <40 years, Group B: 40–60 years and Group C: >60 years. The most frequent immunosuppressive regimen included tacrolimus, mycophenolate mofetil and steroids. Results. Patients were distributed as follows: 25.85% in Group A (>40 years), 50.9% in Group B (40–60 years) and 23.19% in Group C (>60). The 5-year survival for the different age groups was 97.4, 90.8 and 77.7%, respectively. Death-censored graft survival was 88, 84.2 and 79.1%, respectively, and non death-censored graft survival was 82.1, 80.3 and 64.7%, respectively. Across all age groups, CVD and infections were the most frequent cause of death. The main causes of graft loss were chronic allograft dysfunction in patients <40 years old and death with functioning graft in the two remaining groups. In the multivariate analysis for graft survival, only elevated creatinine levels and proteinuria >1 g at 6 months post-transplantation were statistically significant in the three age groups. The patient survival multivariate analysis did not achieve a statistically significant common factor in the three age groups. Conclusions. Five-year results show an excellent recipient survival and graft survival, especially in the youngest age group. Death with functioning graft is the leading cause of graft loss in patients >40 years. Early improvement of renal function and proteinuria together with strict control of cardiovascular risk factors are mandatory. application/pdf https://uvadoc.uva.es/handle/10324/50939 eng Oxford University Press European Renal Association Riñones - Trasplante Mortalidad Survival Supervivencia Riñones - Enfermedades 3205.06 Nefrología 3205.01 Cardiología Risk factors for graft loss and mortality after renal transplantation according to recipient age: a prospective multicentre study info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana