2026-04-27T22:02:30Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/513832022-09-30T10:51:03Zcom_10324_1185com_10324_931com_10324_894col_10324_1346

Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study Escobedo Monge, Marlene Fabiola Torres Hinojal, María Carmen Barrado Esteban, Enrique Escobedo Monge, María Antonieta Marugán de Miguelsanz, José Manuel Parodi Román, Joaquín Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropomet-ric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaning-fully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population. 2022-01-14T10:43:29Z 2022-01-14T10:43:29Z 2021 info:eu-repo/semantics/article Nutrients, 2021, vol. 13, 3578 2072-6643 https://uvadoc.uva.es/handle/10324/51383 10.3390/nu13103578 3578 NUTRIENTS 13 eng https://www.mdpi.com/2072-6643/13/10/3578 info:eu-repo/semantics/openAccess © 2021 The Authors MDPI SI