2026-05-05T21:34:48Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/517092025-01-22T09:07:00Zcom_10324_1181com_10324_931com_10324_894col_10324_1387

00925njm 22002777a 4500 dc Arjona Valladares, Antonio author Fondevila Estévez, Sabela author Fernández Linsenbarth, Ines author Díez Revuelta, Álvaro author Ruiz Sanz, Francisco Javier author Rodríguez Lorenzana, Alberto author Molina Rodríguez, Vicente author 2021 Mapping of Event-Related Potentials (ERP) associated with auditory and visual odd-ball paradigms has shown consistent differences between healthy controls and schizophrenia patients. It may be hypothesized that higher task attentional/cognitive demand will result in larger differences in these paradigms, which may help understanding the substrates of cognitive deficits in this syndrome. To this aim, we performed an EEG study comparing the effects of increasing the attentional/cognitive load of an auditory N-back task on the Event-Related Potential in 50 subjects with schizophrenia (11 first episodes) and 35 healthy controls. We considered a post-target window of 1000 ms to explore possible between groups differences in N100, P300, and Late Slow Wave (LSW), and compared these components between 0-back (‘lower attentional/cognitive load) and 1-back (‘higher attentional/cognitive load’) conditions. Our results showed that N100 and LSW amplitude increase from 0- to 1-back condition was significantly larger in healthy controls compared to schizophrenia patients. Furthermore, LSW amplitude difference between 0- and 1-back conditions positively correlated with performance in the behavioral cognitive assessment. Taken together, these results support that higher task attentional/cognitive load (0-back vs. 1-back condition) increase N100 amplitude differences and reveal new findings related to the LSW component in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021, vol. 111, 110347 0278-5846 https://uvadoc.uva.es/handle/10324/51709 10.1016/j.pnpbp.2021.110347 Event-related potentials associated to N-back test performance in schizophrenia