2026-04-30T05:22:00Zhttps://uvadoc.uva.es/oai/request
oai:uvadoc.uva.es:10324/522062024-12-13T09:23:01Zcom_10324_1181com_10324_931com_10324_894col_10324_1387
UVaDOC author Iglesias Tejedor, María author Díez Revuelta, Álvaro author Llorca Bofí, Vicent author Núñez Novo, Pablo author Castaño Díaz, Carolina author Bote, Berta author Segarra, Rafael author Sanz Fuentenebro, Javier author Molina Rodríguez, Vicente 2022-03-01T08:41:34Z 2022-03-01T08:41:34Z 2022 Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2022, vol. 116, 110541 0278-5846 https://uvadoc.uva.es/handle/10324/52206 10.1016/j.pnpbp.2022.110541 There is some consistency in previous EEG findings that patients with schizophrenia have increased resting-state cortical activity. Furthermore, in previous work, we have provided evidence that there is a deficit in the modulation of bioelectrical activity during the performance of a P300 task in schizophrenia. Our hypothesis here is that a basal hyperactivation would be related with altered ability to change or modulate cortical activity during a cognitive task. However, no study so far, to the best of our knowledge, has studied the association between resting-state activity and task-related modulation. With this aim, we used a dual EEG paradigm (resting state and oddball task for elicitation of the P300 evoked potential) in a sample of patients with schizophrenia (n = 100), which included a subgroup of patients with first episode psychosis (n = 30), as well as a group of healthy controls (n = 93). The study measures were absolute power for resting-state; and spectral entropy (SE) and connectivity strength (CS) for P300-task data, whose modulation had been previously found to be altered in schizophrenia. Following the literature on P300, we focused our study on the theta frequency band. As expected, our results showed an increase in resting state activity and altered task-related modulation. Moreover, we found an inverse relationship between the amount of resting-state activity and modulation of task-related activity. Our results confirm our hypothesis and support the idea that a greater amount of resting theta-band synchrony could hamper the modulation of signal regularity (quantified by SE) and activity density (measured by CS) during the P300 task performance. This association was found in both patients and controls, suggesting the existence of a common mechanism and a possible ceiling effect in schizophrenia patients in relation to a decreased inhibitory function that limits their cortical reactivity to the task. eng Attribution-NonCommercial-NoDerivatives 4.0 Internacional Relation between EEG resting-state power and modulation of P300 task-related activity in theta band in schizophrenia info:eu-repo/semantics/article URL https://uvadoc.uva.es/bitstream/10324/52206/1/Relation-between-EEG-resting-state-power.pdf File MD5 dd14da6240ec7fe92c051ebd1a25ded7 4233721 application/pdf Relation-between-EEG-resting-state-power.pdf