2026-04-14T19:28:01Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/525322022-07-18T09:32:59Zcom_10324_1187com_10324_931com_10324_894col_10324_1408

Díez Poza, Carlos Val, Patricia Pulido Pelaz, Francisco José Barbero Pérez, María Asunción 2018 Producción Científica Tetrahydropyrans are abundantly found in marine natural products. The interesting biological properties of these compounds and their analogues make necessary the development of convenient procedures for their synthesis. In this paper, an atom economy access to tetrahydropyrans by intramolecular acid-mediated cyclization of silylated alkenols is described. p-TsOH has shown to be an efficient reagent to yield highly substituted tetrahydropyrans. Moreover, excellent diastereoselectivities are obtained both for unsubstituted and alkylsubstituted vinylsilyl alcohols. The methodology herein developed may potentially be applied to the synthesis of marine drugs derivatives. application/pdf https://uvadoc.uva.es/handle/10324/52532 eng MDPI 23 Química 24 Ciencias de la Vida Synthesis of polysubstituted tetrahydropyrans by stereoselective hydroalkoxylation of silyl alkenols: En route to tetrahydropyranyl marine analogues info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana