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Merino Antolín, Beatriz Fernández Díaz, Cristina María Cózar Castellano, Irene Perdomo Hernández, Germán 2022-04-07T11:51:24Z 2022-04-07T11:51:24Z 2020 Nutrients, 2020, vol. 12, n. 1, 94 2072-6643 https://uvadoc.uva.es/handle/10324/52814 10.3390/nu12010094 Producción Científica The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed. Ministerio de Economía, Industria y Competitividad (grants SAF2016-77871-C2-1-R and SAF2016-77871-C2-2-R) Fundación La-Caixa - Fundación Caja de Burgos (grant CAIXA-UBU001) application/pdf eng MDPI info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2020 The Authors Atribución 4.0 Internacional Fructose Fructosa Glucose Glucosa Intestine Intestino Intestinal fructose and glucose metabolism in health and disease info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.mdpi.com/2072-6643/12/1/94 SI