2026-05-05T11:21:33Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/539342022-07-18T09:33:02Zcom_10324_22821com_10324_954com_10324_894col_10324_22822

Deng, X. Hasan, A. Elsharkawy, S. Tejeda Montes, E. Tarakina, N.V. Greco, G. Nikulina, E Stormonth-Darling, J.M. Convery, N. Rodríguez Cabello, José Carlos Boyde, A. Gadegaard, N. Pugno, N.M. Al-Jawad, M. Mata, A. Producción Científica Material platforms based on interaction between organic and inorganic phases offer enormous potential to develop materials that can recreate the structural and functional properties of biological systems. However, the capability of organic-mediated mineralizing strategies to guide mineralization with spatial control remains a major limitation. Here, we report on the integration of a protein-based mineralizing matrix with surface topog- raphies to grow spatially guided mineralized structures. We reveal how well-defined geometrical spaces defined within the organic matrix by the surface topographies can trigger subtle changes in single nanocrystal co- alignment, which are then translated to drastic changes in mineralization at the microscale and macroscale. Furthermore, through systematic modifications of the surface topographies, we demonstrate the possibility of selectively guiding the growth of hierarchically mineralized structures. We foresee that the capacity to direct the anisotropic growth of such structures would have important implications in the design of biomineralizing syn- thetic materials to repair or regenerate hard tissues. 2022-07-13 2022-07-13 2021 info:eu-repo/semantics/article Materials Today Bio, 2021, vol. 11, p. 100119 2590-0064 https://uvadoc.uva.es/handle/10324/53934 10.1016/j.mtbio.2021.100119 100119 Materials Today Bio 11 eng https://www.sciencedirect.com/science/article/pii/S2590006421000272 info:eu-repo/grantAgreement/EC/H2020/732344 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ © 2021 The Author(s) © 2021 Elsevier Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier