2026-04-28T21:12:50Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/55402022-07-29T08:20:07Zcom_10324_1132com_10324_931com_10324_894col_10324_1205

Moro Balbás, José Antonio Carretero, José Alonso Revuelta, María Isabel Martín, C. Gato Casado, Ángel Luis Mano Bonín, Anibal de la 2014-07-22T10:38:48Z 2014-07-22T10:38:48Z 2008 Citokine, XXX, 2008 http://uvadoc.uva.es/handle/10324/5540 10.1016/j.cyto.2008.08.005 1 XXX 8 Citokine XXX Producción Científica It is known that interleukin 1b (IL-1b) and interleukin 6 (IL-6) are expressed post-natally in normal and tumoral cells in the anterior pituitary, and that they play a role in both the liberation of different hormones and in the growth, proliferation and tumor formation of the pituitary gland. However, their expression and role during embryonic and fetal development remain unknown. We have performed an immunocytochemistry study of prenatal expression and distribution of IL-1b and IL-6 in isolated embryonic rat Rathke’s pouch prior to birth, more specifically between 13.5 and 19.5 days p.c. Western-blot analysis carried out on 19.5-day p.c. embryos showed positive immunolabelling for IL-1b and IL-6. These interleukins were initially expressed simultaneously in the rostral and ventral portions of Rathke’s pouch in 15.5-day p.c. embryos, and this expression progressed caudodorsally in later developmental stages, extending to most of the hypophysis before birth. The number of cells expressing these interleukins increased throughout this period: 48.22% of anterior pituitary cells expressed IL-6 in 19.5-day embryos, whilst IL-1b was positive in 39.8% of the cells. Moreover, we have demonstrated that some adenohypophyseal cells co-express both interleukins. Such findings represent the first step towards an understanding of the physiological role of these interleukins in anterior pituitary development. application/pdf eng Elsevier info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Citoquímica Hipófisis - Cáncer Prenatal expression of interleukin 1B and interleukin 6 in the rat pituitary gland info:eu-repo/semantics/article https://www.sciencedirect.com/science/article/pii/S1043466608006881 SI