2026-04-14T21:08:53Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/557002025-03-04T09:47:53Zcom_10324_55675com_10324_954com_10324_894col_10324_55676
UVaDOC
author
Aguado Vesperinas, Raúl
author
Sanz Novo, Miguel
author
Mata López, Santiago
author
León Ona, Iker
author
Alonso Hernández, José Luis
2022-09-28T08:56:25Z
2022-09-28T08:56:25Z
2022
The Journal of Physical Chemistry A, 2022, vol. 126, n. 42, p. 7621–7626
1089-5639
https://uvadoc.uva.es/handle/10324/55700
10.1021/acs.jpca.2c04595
In the present work, we report the first rotational study of N-acetylgalactosamine, a cancer-associated sugar derivative, by means of high-resolution rotational spectroscopy. Two different conformers have been conclusively characterized using broadband Fourier transform microwave spectroscopy coupled with a laser ablation vaporization system. Additionally, we performed a comprehensive analysis of the intramolecular interactions that govern these structures, which allowed us to both characterize the existence of intramolecular hydrogen bond networks that drive the intrinsic conformation panorama of N-acetylgalactosamine and further rationalize the biological role of this aminosugar derivative as part of the Tn antigen.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Unveiling the shape of N-Acetylgalactosamine: A cancer-associated sugar derivative
info:eu-repo/semantics/article
URL
https://uvadoc.uva.es/bitstream/10324/55700/1/Unveiling-shape-N-Acetylgalactosamine.pdf
File
MD5
4f005b94e70d2ec6d7edbeb7fbbc92e6
2363259
application/pdf
Unveiling-shape-N-Acetylgalactosamine.pdf