2026-04-14T13:17:04Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/577632024-12-13T12:17:25Zcom_10324_1132com_10324_931com_10324_894col_10324_1205

Fernández Lázaro, Diego García Hernández, Juan Luis Caballero García, Alberto Caballero del Castillo, Aurora Villaverde Hueso, María Cruz Hernández, Juan Jesús 2022-12-14T08:54:10Z 2022-12-14T08:54:10Z 2020 Diagnostics, 2020, Vol. 10, Nº. 7, 443 2075-4418 https://uvadoc.uva.es/handle/10324/57763 10.3390/diagnostics10070443 443 7 Diagnostics 10 2075-4418 Producción Científica The term liquid biopsy (LB) refers to the study of circulating tumor cells, circulating tumors nucleic acids free of cells or contained in exosomes, and information about platelets associated with tumors. LB can be performed in different biofluids and allows the limitations of tissue biopsy to be overcome offering possibilities of tumor identification reflecting in real time tumor heterogeneity. In addition, LB allows screening and early detection of cancer, real-time monitoring of therapy, stratification and therapeutic intervention, a therapeutic target and resistance mechanism, and a risk of metastatic relapse. Currently, LB has been shown to be effective for its application in different types of tumors including lung, colorectal, prostate, melanoma, breast and pancreatic cancer, by the determination and identification of biomarkers that with a high probability have the potential to change the way in which medical oncology could predict the course of the disease. These biomarkers make it possible to capture the heterogeneity of the cancer, monitor its clonal evolution, indicate new treatments or retreatments and evaluate the responses to different evolutionary and/or therapeutic pressures in the cancer disease. application/pdf eng MDPI info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2020 The Author(s) Atribución 4.0 Internacional Cancer research Cancer - Early detection Cancer - Molecular aspects Liquid Biopsy General practice (Medicine) Translational Medical Research 3207.13 Oncología Clinical perspective and translational oncology of liquid biopsy info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.mdpi.com/2075-4418/10/7/443 SI