2026-05-05T18:33:46Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/58812021-06-23T11:41:28Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

Bone mineral density, bone remodeling and osteoprotegerin in patients with acute coronary syndrome Pérez Castrillon, José Luis Abad Manteca, Laura Vega, Gemma Sanz Cantalapiedra, Alberto San Miguel, Ángel Mazón Ramos, María de los Ángeles Luis Román, Daniel Antonio de Dueñas Laita, Antonio Osteoporosis The objective of this study was to evaluate the relationship between coronary disease and osteoporosis and determine the effect of osteoprotegerin (OPG) on bone remodeling and bone mineral density (BMD) in a group of patients with acute coronary syndrome. Eightythree patients (52 males and 31 women) with acute coronary syndrome (75 patients with acute myocardial infarction and 8 with unstable angina) with an average age of 61±10 years were studied. Levels of osteocalcin, urinarydeoxypyridinoline, OPG and the receptor activator of nuclear factor-κB ligand (RANKL) were determined during the hospital stay. Femoral neck, trochanter and lumbar spine densitometry was carried out using a DXA densitometer. Thirty percent of patients presented osteoporosis (39% of females and 26% of males). Osteoporotic patients were older and had a lower weight and height and elevated serum levels of osteocalcin (3.6±2.25 2.63 versus ±1.55, p=0.05). Levels of OPG and RANKL were similar in both groups and showed no relationship with BMD. In conclusion, no relationship was observed between the OPG/RANKL system and BMD in these patients. 2014-09-09T10:56:29Z 2014-09-09T10:56:29Z 2014-09-09T10:56:29Z 2008 info:eu-repo/semantics/article International Journal of Cardiology, 2008, vol. 129, p. 144-145 0167-5273 http://uvadoc.uva.es/handle/10324/5881 10.1016/j.ijcard.2007.06.035 144 145 International Journal of Cardiology 129 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Elsevier Ireland Ltd.