2026-04-27T21:26:00Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/58822025-02-10T13:16:31Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

Relation of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naı¨ve diabetes obese patients Luis Román, Daniel Antonio de González Sagrado, Manuel Conde, R. Aller de la Fuente, Rocío Izaola Jauregui, Olatz Fuente, Beatriz de la Pérez Castrillon, José Luis Romero, E. Cardiovascular, Aparato - Enfermedades Diabetes Producción Científica Background: The aim of the present study was to explore the relationship of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naı¨ve diabetic patients. Subjects: A population of 66 naı¨ve diabetic patients with obesity was analyzed. A complete nutritional and biochemical evaluation was performed. Results: The mean age 56.9 11.6 years and the mean BMI was 37.8 6.3. Patients were divided in two groups by median resistin value (3.3 ng/ml), group I (patients with the low values, average value 2.5 0.5) and group II (patients with the high values, average value 4.8 1.8). Patients in the group I had lower waist circumference, total cholesterol, LDLcholesterol and C-reactive protein than patients in group II. Correlation analysis showed a significant correlation among resistin levels and the independent variables; BMI (r = 0.26; p < 0.05), waist circumference (r = 0.38; p < 0.05), fat mass (r = 0.28; p < 0.05), LDL-cholesterol (r = 0.3; p < 0.05), C-reactive protein (r = 0.28; p < 0.05). In the multivariate analysis, resistin concentration increase 0.024 ng/ml (CI 95%: 0.006–0.42) for each mg/dl of C-reactive protein. Conclusion: Circulating resistins are associated with C-reactive protein in an independent way in naı¨ve diabetic patients. 2014-09-09T11:30:19Z 2014-09-09T11:30:19Z 2010 info:eu-repo/semantics/article Diabetes Research and Clinical Practice, 2010, vol. 89, p. 110-114 0168-8227 http://uvadoc.uva.es/handle/10324/5882 10.1016/j.diabres.2010.03.031 110 114 Diabetes Research and Clinical Practice 89 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Elsevier SI