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oai:uvadoc.uva.es:10324/589722023-03-17T20:02:42Zcom_10324_1133com_10324_931com_10324_894col_10324_1209

Rojo Rodriguez, María de los Ángeles Garrosa García, Manuel Jiménez López, María del Pilar Girbés Juan, Tomás García Recio, Verónica Córdoba Diaz, Manuel Córdoba Diaz, Damián 2023-03-17T13:02:10Z 2023-03-17T13:02:10Z 2020 Toxins, 2020, Vol. 12, Nº. 9, 542 2072-6651 https://uvadoc.uva.es/handle/10324/58972 10.3390/toxins12090542 542 9 Toxins 12 2072-6651 Producción Científica The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder (Sambucus ebulus L.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administration of these same doses of both Polyphenon 60 and ebulin f triggered an important and unexpected synergistic toxic action featured by the biphasic reduction of weight, which continued after eight days, reaching a reduction of 40%. Lethality appeared 2 days after the onset of the combined treatment and reached more than 50% after 10 days. Junta de Castilla y León y Consejería de Sanidad (GR106) application/pdf eng MDPI info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2020 The Authors Atribución 4.0 Internacional Polyphenols Té verde Lectinas Sambucus ebulus Ebulin f RIP Ribosome-inactivating protein Ricin 3214 Toxicología 3206.11 Toxicidad de Los Alimentos Unexpected toxicity of green tea polyphenols in combination with the Sambucus RIL ebulin info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.mdpi.com/2072-6651/12/9/542 SI