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oai:uvadoc.uva.es:10324/590802025-02-21T10:04:53Zcom_10324_1176com_10324_931com_10324_894col_10324_1359

00925njm 22002777a 4500 dc Bello Gutierrez, Hugo José author Caballero García, Alberto author Pérez Valdecantos, Daniel author Roche Collado, Enrique author Noriega González, David César author Córdova Martínez, Alfredo author 2021 Vitamin D is a key micronutrient modulating function and health in skeletal muscle. Therefore, we sought to systematically review the role of vitamin D in muscle recovery. A search in different databases (PubMed/MEDLINE, WOS, Google Scholar, and Scopus) was carried out following PRISMA® and PICOS. The search period was from inception to April 2020. Changes in post-exercise muscle damage were quantified comparing experimental group vs. placebo in each study by using number of participants, standardized mean difference (SMD), and standard error of the SMD. Hedges’s g was used to calculate the SMDs for each study group and biased by the inverse of variance that allows calculating an overall effect and the 95% confidence interval (CI). The net vitamin D supplementation effect was calculated by subtracting the placebo SMD from SMD of the experimental group. The DerSimonian and Laird method was used as a random effect model, taking into account that the effect of vitamin D on muscular damage may vary according to the dose administered and additional moderators. Six studies were selected. In conclusion, regarding circulating levels of muscle biomarkers and additional limitations of the studies, it cannot be concluded that vitamin D supplementation exerts an effect in post-exercise muscle recovery. Likely, the anti-inflammatory action of vitamin D is quicker than the recovery of tissue structure and function. This aspect is pending verification in future research. Nutrients, 2021, Vol. 13, Nº. 11, 4013 2072-6643 https://uvadoc.uva.es/handle/10324/59080 10.3390/nu13114013 4013 11 Nutrients 13 2072-6643 Creatine kinase Ejercicio Ejercicio físico Vitamin D Systematic reviews (Medical research) Meta-analysis Effects of vitamin D in post-exercise muscle recovery. A systematic review and meta-analysis