2026-04-27T21:42:44Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/592082025-02-19T12:07:21Zcom_10324_1132com_10324_931com_10324_894col_10324_1205

Caballero García, Alberto Pascual Fernández, Jorge Noriega González, David César Bello Gutierrez, Hugo José Pons Biescas, Antoni Roche Collado, Enrique Córdova Martínez, Alfredo 2021 Producción Científica Sarcopenia is a process associated to aging. Persistent inflammation and oxidative stress in muscle favour muscle wasting and decreased ability to perform physical activity. Controlled exercise can optimize blood flux and moderate the production of reactive oxygen species. Therefore, supplements that can work as a vasodilators and control oxidative stress, might be beneficial for active elders. In this context, we have tested citrulline supplementation in a group of 44 participants aged from 60–73 years that followed a physical activity program adapted to their age and capacities. Volunteers were divided in two groups: placebo (n = 22) and citrullline supplemented (n = 22). Different physical tests and blood extractions were performed at the beginning and at the end of intervention (six weeks). Strength and endurance showed a tendency to increase in the citrulline supplemented group, with no significant differences respect to placebo. However, walking speed in the citrulline supplemented group improved significantly compared to placebo. Markers of muscle damage as well as circulating levels of testosterone, cortisol and vitamin D showed no significant changes, but a tendency to improve at the end of intervention in the supplemented group compared to placebo. Additional studies are necessary to confirm the effect of citrulline supplementation in sarcopenia delay. application/pdf https://uvadoc.uva.es/handle/10324/59208 eng MDPI Fisiología Geriatrics Envejecimiento 2410.02 Anatomía Humana 2411.10 Fisiología del Músculo L-citrulline supplementation and exercise in the management of sarcopenia info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana