2026-05-05T19:42:59Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/594142026-04-09T10:21:30Zcom_10324_1138com_10324_931com_10324_894col_10324_1226

00925njm 22002777a 4500 dc Mateos Olivares, Milagros author García Onrubia, Luis author Valentín Bravo, Francisco Javier author González Sarmiento, Rogelio author López Gálvez, María Isabel author Pastor Jimeno, José Carlos author Usategui Martín, Ricardo author Pastor Idoate, Salvador author 2021 Diabetic macular oedema (DMO) is one of the leading causes of vision loss associated with diabetic retinopathy (DR). New insights in managing this condition have changed the paradigm in its treatment, with intravitreal injections of antivascular endothelial growth factor (anti-VEGF) having become the standard therapy for DMO worldwide. However, there is no single standard therapy for all patients DMO refractory to anti-VEGF treatment; thus, further investigation is still needed. The key obstacles in developing suitable therapeutics for refractory DMO lie in its complex pathophysiology; therefore, there is an opportunity for further improvements in the progress and applications of new drugs. Previous studies have indicated that Rho-associated kinase (Rho-kinase/ROCK) is an essential molecule in the pathogenesis of DMO. This is why the Rho/ROCK signalling pathway has been proposed as a possible target for new treatments. The present review focuses on the recent progress on the possible role of ROCK and its therapeutic potential in DMO. A systematic literature search was performed, covering the years 1991 to 2021, using the following keywords: “rho-Associated Kinas-es”, “Diabetic Retinopathy”, “Macular Edema”, “Ripasudil”, “Fasudil” and “Netarsudil”. Better insight into the pathological role of Rho-kinase/ROCK may lead to the development of new strategies for refractory DMO treatment and prevention. Cells 2021, Vol. 10, Nº. 7, 1683 2073-4409 https://uvadoc.uva.es/handle/10324/59414 10.3390/cells10071683 1683 7 Cells 10 2073-4409 Diabetic retinopathy Retina - Enfermedades Diabetes - Complicaciones y secuelas Protein kinases Ojos - Enfermedades Rho-kinase inhibitors for the treatment of refractory diabetic macular oedema