2026-04-14T18:11:42Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/59432025-02-10T13:15:07Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

Effect of the TNF -308 G/A Polymorphism on the Changes Produced by Atorvastatin in Bone Mineral Density in Patients with Acute Coronary Syndrome Pérez Castrillon, José Luis Vega, Gemma Abad Manteca, Laura Sanz Cantalapiedra, Alberto González Sagrado, Manuel Luis Román, Daniel Antonio de Dueñas Laita, Antonio Huesos - Enfermedades Cardiovascular, Aparato - Enfermedades Producción Científica Aims: To evaluate the effect of atorvastatin on bone mass and markers of bone remodeling in patients with acute coronary syndrome depending on the tumor necrosis factor- (TNF )-308 G/A polymorphism. Methods: Sixty-two patients with acute coronary syndrome (35 males and 27 females), average age 60 8 10 years, were included. Patients were given low (10–20 mg) and high doses (40–80 mg) atorvastatin according to their baseline levels of cholesterol and triglycerides and their index of vascular risk. Patients were studied during hospital admission (baseline) and at 12 months of follow-up. Cholesterol, triglycerides, total calcium, phosphorus, magnesium, osteocalcin and urinary deoxypyridinoline were determined in all patients at baseline and at 12 months of follow-up. Densitometric studies were conducted in the lumbar spine (L 2 –L 4 ), femoral neck and trochanter using an X-ray densitometer. The TNF -308 G/A polymorphism was determined by the polymerase chain reaction. Results: Forty-five patients were homozygous for G/G (72.5%) and 17 were heterozygous for G/A (27.5%). The prevalence of osteoporosis (T score ^ 2.5 in the lumbar spineand/or hip) was 33% for the G/G genotype and 35% for the G/A genotype, with no statistically significant differences between groups. There was a statistically significant increase in bone mineral density (BMD) in the lumbar spine (1.107 8 0.32 vs. 1.129 8 0.23; p = 0.0001) in patients with the G/G genotype. No changes were observed in patients with the G/A genotype. Conclusion: In patients with acute coronary syndrome, atorvastatin increases lumbar spine BMD solely in patients with the G/G genotype of the TNF -308 G/A polymorphism. 2014-09-15T08:20:24Z 2014-09-15T08:20:24Z 2008 info:eu-repo/semantics/article Annals of Nutrition and Metabolism, 2008, vol. 53, p. 117-121 0250-6807 http://uvadoc.uva.es/handle/10324/5943 10.1159/000170886 117 121 Annals of Nutrition and Metabolism 53 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Karger SI