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Caballero García, Alberto Córdova Martínez, Alfredo Vicente Salar, Néstor Roche Collado, Enrique Pérez Valdecantos, Daniel 2023-05-02T11:03:09Z 2023-05-02T11:03:09Z 2021 Nutrients 2021, Vol. 13, Nº. 7, 2336 2072-6643 https://uvadoc.uva.es/handle/10324/59453 10.3390/nu13072336 2336 7 Nutrients 13 2072-6643 Aside from its role in bone metabolism, vitamin D is a key immunomodulatory micronutrient. The active form of vitamin D (1,25(OH)D) seems to modulate the innate immune system through different mechanisms. The vitamin is involved in the differentiation of monocytes into macrophages, increasing the phagocytic and chemotactic functions of these cells. At the same time, vitamin D enables efferocytosis and prevents immunopathology. In addition, vitamin D is involved in other processes related to immune function, such as inflammation. Regarding muscle tissue, vitamin D plays an active role in muscle inflammatory response, protein synthesis, and regulation of skeletal muscle function. Two mechanisms have been proposed: A direct role of 1,25(OH)D binding to vitamin D receptors (VDRs) in muscle cells and the modulation of calcium transport in the sarcoplasmic reticulum. This second mechanism needs additional investigation. In conclusion, vitamin D seems to be effective in cases of deficiency and/or if there is a great muscular commitment, such as in high intensity exercises. eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2021 The authors Atribución 4.0 Internacional Exercice Sports Ejercicio físico Immunology Inflammation Vitamin D Vitamin D, its role in recovery after muscular damage following exercise info:eu-repo/semantics/article