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oai:uvadoc.uva.es:10324/59482026-03-27T09:31:24Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

00925njm 22002777a 4500 dc Pérez Castrillon, José Luis author Olmos, José Manuel author Nan, Daniel N. author Castillo Vegas, Jesús Luis author Arozamena, Jana author Montero, Antonio author Pérez Núñez, María I. author Riancho Moral, José Antonio author 2009 Wnt ligands are important regulators of skeletal homeostasis. Wnt10B tends to stimulate the differentiation of common mesenchymal precursors toward the osteoblastic lineage, while inhibiting adipocytic differentiation. Hence, we decided to explore the association of WNT10B allelic variants with bone mineral density and osteoporotic fractures. A set of tag SNPs capturing most common variations of the WNT10B gene was genotyped in 1438 Caucasian postmenopausal women, including 146 with vertebral fractures and 432 with hip fractures. We found no association between single SNPs and spine or hip bone mineral density (BMD). In the multilocus analysis, some haplotypes showed a slight association with spine BMD (P = 0.03), but it was not significant after multiple-test correction. There was no association between genotype and vertebral or hip fractures. Transcripts of WNT10B and other Wnt ligands were detected in human bone samples by real-time PCR. However, there was no relationship between genotype and RNA abundance. Thus, WNT10B is expressed in the bone microenvironment and may be an important regulator of osteoblastogenesis, but we have not found evidence for a robust association of common WNT10B gene allelic variants with either BMD or fractures in postmenopausal women. Calcified Tissue International, 2009, vol. 85, p. 113-118 0171-967X http://uvadoc.uva.es/handle/10324/5948 10.1007/s00223-009-9256-4 113 118 Calcified Tissue International 85 Osteoporosis Huesos-Fracturas Polymorphisms of the WNT10B Gene, Bone Mineral Density, and Fractures in Postmenopausal Women