2026-04-27T21:29:00Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/59692024-12-16T12:06:27Zcom_10324_1133com_10324_931com_10324_894col_10324_1209

Modulation of mitochondrial Ca2+ uptake by estrogen receptor agonists and antagonists Domínguez Lobatón, María Carmen Vay, Laura Hernández San Miguel, Esther Santo Domingo Mayoral, Jaime Moreno Díaz-Calderón, Alfredo Montero Zoccola, María Teresa Álvarez Martín, Javier Hormonas femeninas - Absorción y adsorción Calcio - Efectos fisiológicos Producción Científica Ca2+ uptake by mitochondria is a key element in the control ofcellular Ca2+ homeostasis and Ca2+-dependent phenomena. It has been known for many years that this Ca2+ uptake is mediated by the mitochondrial Ca2+ uniporter, a specific Ca2+ channel ofthe inner mitochondrial membrane. We have shown previously that this channel is strongly activated by a series ofnatural phytoestrogenic flavonoids. We show here that several agonists and antagonists of estrogen receptors (ERs) also modulate the activity ofthe uniporter. 2014-09-16T07:49:09Z 2015-09-16T23:40:09Z 2005 info:eu-repo/semantics/article British Journal of Pharmacology, 2005, vol. 145, p. 862-871 0007-1188 http://uvadoc.uva.es/handle/10324/5969 10.1038/sj.bjp.0706265 862 871 British Journal of Pharmacology 145 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Nature Publishing Group SI