2026-04-27T22:10:19Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/598572023-06-15T19:00:35Zcom_10324_1179com_10324_931com_10324_894col_10324_1306
Bonaterra Pastra, Anna
Fernández de Retana, Sofia
Rivas Urbina, Andrea
Puig, Nuria
Benítez, Sonia
Pancorbo, Olalla
Rodríguez Luna, David
Pujadas, Francesc
Freijo Guerrero, María del Mar
Tur, Silvia
Martínez Zabaleta, Maite
Cardona Portela, Pere
Vera, Rocío
Lebrato Hernández, Lucía
Arenillas Lara, Juan Francisco
Pérez Sánchez, Soledad
Montaner, Joan
Sánchez Quesada, Jose Luis
Hernández Guillamon, Mar
2023-06-15T10:11:14Z
2023-06-15T10:11:14Z
2021
Biomedicines, 2021, Vol. 9, Nº. 1, 72
2227-9059
https://uvadoc.uva.es/handle/10324/59857
10.3390/biomedicines9010072
72
1
Biomedicines
9
2227-9059
Producción Científica
Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer’s disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation.
Instituto de Salud Carlos III y Fondo Europeo de Desarrollo Regional (FEDER) - (grant PI13/00364, PI16/00471, PI14/01134 and PI17/00275)
Instituto de Salud Carlos III - (grant FI17/00031)
Instituto de Salud Carlos III, Programa Miguel Servet - (grant CPII17/00010)
Instituto de Salud Carlos III - (project RD16/0019/0021)
Generalitat de Catalunya - (Grupo 2017-SGR-1149)
application/pdf
eng
MDPI
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2021 The authors
Atribución 4.0 Internacional
Alzheimer's disease
Alzheimer, Enfermedad de
Lipids
Neurology
Cerebro - Enfermedades
Lípidos
Proteins
Proteinas
3207.11 Neuropatología
Comparison of plasma lipoprotein composition and function in cerebral amyloid angiopathy and Alzheimer’s disease
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://www.mdpi.com/2227-9059/9/1/72
SI