2026-05-05T20:44:59Zhttps://uvadoc.uva.es/oai/request
oai:uvadoc.uva.es:10324/599562023-06-26T19:00:23Zcom_10324_1149com_10324_931com_10324_894col_10324_1274
UVaDOC author Castro Alija, María José author Jiménez Pérez, José María author López Vallecillo, María author Cao Torija, María José author Santos Torres, Jair author López, Alberto author Moreno, Ana author Ruiz-Tovar Polo, Jaime 2023-06-26T11:28:06Z 2023-06-26T11:28:06Z 2021 Nutrients, 2021, Vol. 13, Nª. 2, 711 2072-6643 https://uvadoc.uva.es/handle/10324/59956 10.3390/nu13020711 711 2 Nutrients 13 2072-6643 Background: The outcome of colorectal cancer is mostly based on TNM classification. There are several factors determining that patients with the same tumoral stage present different outcomes. The nutritional status has been related to the immunological response and may affect the oncologic results. The purpose of this study was to determine if preoperative nutritional parameters may predict the oncologic outcome in patients with early colorectal cancer. Methods: A prospective observational study of patients undergoing elective surgery for colorectal cancer was performed with stage I. Preoperative nutritional assessment included glycemic and lipid profiles, total proteins, and albumin levels. These parameters were correlated with tumoral recurrence during a follow-up of at least 24 months. Results: During the period of study, 744 patients were operated on and 228 (30.6%) followed the inclusion criteria for this study. Recurrence rate was 5.7% (13 patients). Patients with hypoproteinemia showed a 7.8-fold greater risk of recurrence during the first 24 months after surgery [OR 7.8 (CI95% 1.3–48), p = 0.012]. Patients with glycated hemoglobin levels (HbA1c) > 6.2% showed a 2.3 increased risk of recurrence [OR 2.3 (CI95% 1.1–4.7; p = 0.01]. Conclusions: Preoperative values of total proteins and HbA1c correlate with the recurrence rate in early colorectal cancer. eng Atribución 4.0 Internacional Surgical oncology Cancer Research Oncology Colorectal Surgery Rectum - Surgery Càncer colorectal Recto - Cáncer Colon - Cáncer Outcome assessment (Medical care) Proteins Proteínas Glycosylated hemoglobin - Measurement Nutrition Impact of preoperative total proteins and glycated hemoglobin on recurrences after early colorectal cancer info:eu-repo/semantics/article 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URL https://uvadoc.uva.es/bitstream/10324/59956/1/Impact-of-Preoperative-Total-Proteins.pdf File MD5 3fe5d75c1acd48729908a02354aaa75f 507445 application/pdf Impact-of-Preoperative-Total-Proteins.pdf