2026-04-22T21:38:13Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/599652023-06-27T19:00:34Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

Marazuela, Paula Bonaterra Pastra, Anna Faura, Júlia Penalba, Anna Pizarro, Jesús Pancorbo, Olalla Rodríguez Luna, David Vert, Carla Rovira, Alex Pujadas, Francesc Freijo Guerrero, María del Mar Tur, Silvia Martínez Zabaleta, Maite Cardona Portela, Pere Vera, Rocío Lebrato Hernández, Lucía Arenillas Lara, Juan Francisco Pérez Sánchez, Soledad Montaner, Joan Delgado, Pilar Hernández Guillamon, Mar 2021 Producción Científica Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA–ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18.6 months) and long-term (38.5 ± 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH. application/pdf https://uvadoc.uva.es/handle/10324/59965 eng MDPI Brain - Hemorrhage Neurology Cerebrovascular diseases Enfermedades cerebrovasculares Magnetic resonance Resonancia magnética Angiopatia Cerebro - Anomalias Neurosurgery 3205.07 Neurología 3207.11 Neuropatología 32 Ciencias Médicas Circulating AQP4 levels in patients with cerebral amyloid angiopathy-associated intracerebral hemorrhage info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana