2026-04-27T12:31:51Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/599652023-06-27T19:00:34Zcom_10324_1179com_10324_931com_10324_894col_10324_1306
Circulating AQP4 levels in patients with cerebral amyloid angiopathy-associated intracerebral hemorrhage
Marazuela, Paula
Bonaterra Pastra, Anna
Faura, Júlia
Penalba, Anna
Pizarro, Jesús
Pancorbo, Olalla
Rodríguez Luna, David
Vert, Carla
Rovira, Alex
Pujadas, Francesc
Freijo Guerrero, María del Mar
Tur, Silvia
Martínez Zabaleta, Maite
Cardona Portela, Pere
Vera, Rocío
Lebrato Hernández, Lucía
Arenillas Lara, Juan Francisco
Pérez Sánchez, Soledad
Montaner, Joan
Delgado, Pilar
Hernández Guillamon, Mar
Brain - Hemorrhage
Neurology
Cerebrovascular diseases
Enfermedades cerebrovasculares
Magnetic resonance
Resonancia magnética
Angiopatia
Cerebro - Anomalias
Neurosurgery
Producción Científica
Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA–ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18.6 months) and long-term (38.5 ± 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.
2023-06-27
2023-06-27
2021
info:eu-repo/semantics/article
Journal of Clinical Medicine, 2021, Vol. 10, Nº. 5, 989
2077-0383
https://uvadoc.uva.es/handle/10324/59965
10.3390/jcm10050989
989
5
Journal of Clinical Medicine
10
2077-0383
eng
https://www.mdpi.com/2077-0383/10/5/989
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2021 The authors
Atribución 4.0 Internacional
MDPI