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oai:uvadoc.uva.es:10324/599932023-06-29T19:00:31Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

00925njm 22002777a 4500 dc Trejo Velasco, Blanca author Estevez Loureiro, Rodrigo author Carrasco Chinchilla, Fernando author Fernández Vázque, Felipe author Arzamendi, Dabit author Pan, Manuel author Pascual, Isaac author Nombela Franco, Luis author Amat Santos, Ignacio Jesús author Freixa, Xavier author Hernández Antolín, Rosa Ana author Trillo Nouche, Ramiro author Andraka Ikazuriaga, Leire author López Mínguez, José R. author Sanmiguel Cervera, Dario author Sanchis, Juan author Diez Gil, José Luis author Ruiz Quevedo, Valeriano author Urbano Carrillo, Cristóbal author Becerra Muñoz, Víctor Manuel author Benito González, Tomás author Li, Chi Hion author Mesa, Dolores author Avanzas, Pablo author Armijo, Germán author Serrador Frutos, Ana María author Sanchis, Laura author Fernández-Golfín Lobán, Covadonga author Cid Álvarez, Belén author Hernández García, José María author Garrote Coloma, Carmen author Fernández Peregrina, Estefanía author Romero, Miguel author León Arguero, Víctor author Cruz González, Ignacio author 2021 Background: Transcatheter mitral valve repair (TMVR) is an effective therapy for high-risk patients with severe mitral regurgitation (MR) but heart failure (HF) readmissions and death remain substantial on mid-term follow-up. Recently, right ventricular (RV) to pulmonary arterial (PA) coupling has emerged as a relevant prognostic predictor in HF. In this study, we aimed to assess the prognostic value of tricuspid annular plane systolic excursion (TAPSE) to PA systolic pressure (PASP) ratio as a non-invasive measure of RV-to-PA coupling in patients undergoing TMVR with MitraClip (Abbott, CA, USA). Methods: Multicentre registry including 228 consecutive patients that underwent successful TMVR with MitraClip. The sample was divided in two groups according to TAPSE/PASP median value: 0.35. The primary combined endpoint encompassed HF readmissions and all-cause mortality. Results: Mean age was 72.5 ± 11.5 years and 154 (67.5%) patients were male. HF readmissions and all-cause mortality were more frequent in patients with TAPSE/PASP ≤ 0.35: Log-Rank 8.844, p = 0.003. On Cox regression, TAPSE/PASP emerged as a prognostic predictor of the primary combined endpoint, together with STS-Score. TAPSE/PASP was a better prognostic predictor than either TAPSE or PASP separately. Conclusions: TAPSE/PASP ratio appears as a novel prognostic predictor in patients undergoing MitraClip implantation that might improve risk stratification and candidate selection. Journal of Clinical Medicine, 2021, Vol. 10, Nº. 5, 1006 2077-0383 https://uvadoc.uva.es/handle/10324/59993 10.3390/jcm10051006 1006 5 Journal of Clinical Medicine 10 2077-0383 Cardiac surgery Cardiology Corazón - Cirugía Pulmonary hypertension Hipertensión pulmonar Echocardiography Mitral valve - Diseases - Imaging Heart valves - Diseases - diagnostic imaging Heart - Diseases Corazón - Enfermedades Prognostic role of TAPSE to PASP ratio in patients undergoing MitraClip procedure