2026-04-26T22:08:07Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/602632025-01-13T10:49:13Zcom_10324_1138com_10324_931com_10324_894col_10324_1226

00925njm 22002777a 4500 dc Maza Solano, Juan author Calvo Henríquez, Christian author Alobid, Isam author Álvarez Cendrero, Marta author Palomares, Óscar author Moreno Luna, Ramón author Santos Pérez, Jaime author González García, Jaime author Sánchez Gómez, Serafín author 2022 Currently, some monoclonal antibodies (mAbs) are being studied for chronic rhinosinusitis with nasal polyps (CRSwNP). Three anti-IL-5 mAb: mepolizumab, reslizumab and benralizumab, have been tested through randomized clinical trials. In this real-life study, we aimed to describe the nasal effects of a cohort of asthmatic adults treated with anti-IL-5 mAb. Methods: We carried out an observational study in adults (≥18 years) on anti-IL-5 mAb treatment. Variables included ACT and SNOT−22 questionnaires, nasal polyps score, blood total IgE levels and blood eosinophil count. Results: Overall, 38 participants were included in the study; 19 patients received mepolizumab, 17 were treated with benralizumab and 2 patients were given reslizumab. There was a statistically significant difference in the ACT and SNOT−22 scores before and after mAb treatment. ACT score increased from 11.05 to 21.5 after treatment (p < 0.001). SNOT−22 decreased from 57 to 37.3 after treatment (p = 0.004). No statistically significant differences between mAb groups were observed regarding the ACT or the SNOT−22 (p = 0.775) response (p = 0.775). In addition, 60.53% of patients obtained a minimal clinically important difference (MCID) in SNOT−22. Conclusions: A significant clinical response based on SNOT−22 score evolution after anti-IL-5 mAb treatment was observed. This study also demonstrated that blood eosinophil count, rather than serum total IgE levels, is the best predictor of asthma symptom improvement, which was assessed through the ACT and SNOT−22 questionnaires. Journal of Clinical Medicine, 2022, Vol. 11, Nº. 23, 7056 2077-0383 https://uvadoc.uva.es/handle/10324/60263 10.3390/jcm11237056 7056 23 Journal of Clinical Medicine 11 2077-0383 Asthma Asma Allergy Otorhinolaryngology Otorrinolaringologia Chronic diseases Enfermedades crónicas Respiratory organs - Diseases Respiratorio, aparato - Enfermedades Pneumology Neumología Nose - Diseases Nariz - Enfermedades Asthma - Treatment Asma - Tratamiento Nasal symptoms in asthmatic patients under treatment with anti-IL-5 monoclonal antibodies. A real-life cohort study