2026-04-22T21:09:10Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/603472024-12-13T12:13:55Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
6-week supplementation with Tribulus terrestris L. to trained male CrossFit® athletes on muscle, inflammation, and antioxidant biomarkers: A randomized, single-blind, placebo-controlled trial
Fernández Lázaro, Diego
Seco Calvo, Jesús
Pascual Fernández, Jorge
Domínguez Ortega, Carlos
Valle Soto, Miguel del
Mielgo Ayuso, Juan Francisco
Herbs - Toxicology
Herbs - Therapeutic use
Dietary supplements
Dietética
Entrenamiento deportivo
Athletics
Atletismo - Entrenamiento
Muscles - Diseases
Músculos - Enfermedades
Inflammation
Inflamación
Exercice
Ejercicio
Oxidative stress
Estrés oxidativo
Pharmacology
Producción Científica
Tribulus terrestris L. (TT) ingredients have anti-inflammatory and antioxidant activities, but their effects on exercise-induced muscle damage (EIMD) in trained athletes are uncertain. The purpose of this single-blind placebo-controlled trial, in accordance with CONSORT guidelines, was to examine the effect of 6 weeks of TT supplementation on muscle metabolism, inflammation biomarkers, and oxidant status. Thirty trained male CrossFit® athletes were randomly assigned to be supplemented with 770 mg/day of TT (intervention group (IG)) or receive a placebo daily (control group (CG)) for 6 weeks. Muscle damage enzymes, inflammation biomarkers, and Total Antioxidant Status (TAS) were assessed at baseline (T1), 21 days after baseline (T2), and after 42 days (T3). Grace, a Workout of the Day, was measured in T1 and T3. Statistical significance (p < 0.05) was found between IG and CG in Lactate Dehydrogenase (LDH), C-reactive protein (CRP), and TAS levels at the end of the follow-up. Furthermore, TAS levels were significantly (p < 0.05) lower at T2 and T3 relative to baseline in the IG, also LDH and CRP increased significantly (p < 0.05) at T2 and T3 relative to baseline in the CG. No significant (p > 0.05) decreases in muscle damage or inflammation biomarkers were observed, although a slight downward trend was observed after 6 weeks for supplemented athletes. TT supplementation could attenuate the CrossFit® training program-induced oxidative stress, muscle damage, and inflammation which could be due to the natural antioxidant and anti-inflammatory properties of TT.
2023-07-17T11:01:04Z
2023-07-17T11:01:04Z
2022
info:eu-repo/semantics/article
International Journal of Environmental Research and Public Health, 2022, Vol. 19, Nº. 23, 16158
1660-4601
https://uvadoc.uva.es/handle/10324/60347
10.3390/ijerph192316158
16158
23
International Journal of Environmental Research and Public Health
19
1660-4601
eng
https://www.mdpi.com/1660-4601/19/23/16158
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2022 The Authors
Atribución 4.0 Internacional
MDPI
SI